Gene: Shc1 (SHC adaptor protein 1) Rattus norvegicus
Symbol: Shc1
Name: SHC adaptor protein 1
Description: Exhibits enzyme binding activity, phosphotyrosine residue binding activity, and signaling receptor binding activity; involved in several processes, including actin cytoskeleton organization, activation of MAPK activity, and response to peptide; localizes to the Shc-EGFR complex, endosome membrane, and nucleus; biomarker of familial hyperlipidemia and hepatocellular carcinoma; orthologous to human SHC1 (SHC adaptor protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: P66shc; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1
Homo sapiens (human) : SHC1 (SHC adaptor protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Shc1 (src homology 2 domain-containing transforming protein C1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shc1 (SHC adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHC1 (SHC adaptor protein 1)
Canis lupus familiaris (dog) : SHC1 (SHC adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shc1 (SHC adaptor protein 1)
Sus scrofa (pig) : SHC1 (SHC adaptor protein 1)
more info ...
Allele / Splice: Shc1em1Mcwi   Shc1em3Mcwi   Shc1em4Mcwi   Shc1em5Mcwi  
Genetic Models: SS-Shc1em1Mcwi SS-Shc1em5Mcwi SS-Shc1em3Mcwi SS-Shc1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02188,745,503 - 188,757,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02208,159,786 - 208,171,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,616,581 - 181,628,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,570,194 - 181,572,439 (+)NCBI
Celera2168,778,680 - 168,790,241 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Shc1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620446
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.