Gene: Fhit (fragile histidine triad diadenosine triphosphatase) Rattus norvegicus
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Symbol: Fhit
Name: fragile histidine triad diadenosine triphosphatase
Description: Exhibits bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity; involved in diadenosine triphosphate catabolic process; localizes to the cytosol, nucleus, and plasma membrane; used to study hepatocellular carcinoma and invasive ductal carcinoma; orthologous to human FHIT (fragile histidine triad); PARTICIPATES IN non-small cell lung carcinoma pathway; purine metabolic pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad; fragile histidine triad gene; fragile histidine triad protein
Orthologs:
Homo sapiens (human) : FHIT (fragile histidine triad diadenosine triphosphatase)  HGNC  Alliance
Mus musculus (house mouse) : Fhit (fragile histidine triad gene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhit (fragile histidine triad diadenosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : FHIT (fragile histidine triad diadenosine triphosphatase)
Canis lupus familiaris (dog) : FHIT (fragile histidine triad)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhit (fragile histidine triad diadenosine triphosphatase)
Sus scrofa (pig) : FHIT (fragile histidine triad diadenosine triphosphatase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Fhit
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620448
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.