Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Siah1 (siah E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Siah1
Name: siah E3 ubiquitin protein ligase 1
Description: Exhibits protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Localizes to the cytoplasm; nucleus; and plasma membrane. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; Wnt signaling pathway; INTERACTS WITH (-)-selegiline; 2,4-dinitrotoluene; 7-NITROINDAZOLE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase SIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; SIAH; siah-1; siah-1a; Siah1a
Orthologs:
Homo sapiens (human) : SIAH1 (siah E3 ubiquitin protein ligase 1)  HGNC  Alliance
Mus musculus (house mouse) : Siah1a (siah E3 ubiquitin protein ligase 1A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Siah1 (siah E3 ubiquitin protein ligase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Canis lupus familiaris (dog) : SIAH1 (siah E3 ubiquitin protein ligase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Siah1 (siah E3 ubiquitin protein ligase 1)
Sus scrofa (pig) : SIAH1 (siah E3 ubiquitin protein ligase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01921,372,163 - 21,395,773 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01932,381,464 - 32,405,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41921,717,141 - 21,740,751 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11921,723,004 - 21,745,060 (+)NCBI
Celera1920,251,923 - 20,275,533 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Siah1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620449
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.