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Gene: Nphs1 (NPHS1 adhesion molecule, nephrin) Rattus norvegicus
Symbol: Nphs1
Name: NPHS1 adhesion molecule, nephrin
Description: Exhibits alpha-actinin binding activity; protein domain specific binding activity; and spectrin binding activity. Predicted to be involved in several processes, including JNK cascade; glomerulus development; and myoblast fusion. Localizes to several cellular components, including membrane raft; plasma membrane; and slit diaphragm. Biomarker of membranous glomerulonephritis and nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
Also known as: nephrin; nephrosis 1 homolog (human); nephrosis 1 homolog, nephrin; nephrosis 1 homolog, nephrin (human); nephrosis 1, congenital, Finnish type; nephrosis 1, congenital, Finnish type (nephrin); NPHS1 nephrin; renal glomerulus-specific cell adhesion receptor
Homo sapiens (human) : NPHS1 (NPHS1 adhesion molecule, nephrin)  HGNC  Alliance
Mus musculus (house mouse) : Nphs1 (nephrosis 1, nephrin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nphs1 (NPHS1 adhesion molecule, nephrin)
Pan paniscus (bonobo/pygmy chimpanzee) : NPHS1 (NPHS1 adhesion molecule, nephrin)
Canis lupus familiaris (dog) : NPHS1 (NPHS1 adhesion molecule, nephrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nphs1 (NPHS1 adhesion molecule, nephrin)
Sus scrofa (pig) : NPHS1 (NPHS1 adhesion molecule, nephrin)
Chlorocebus sabaeus (African green monkey) : NPHS1 (NPHS1 adhesion molecule, nephrin)
Heterocephalus glaber (naked mole-rat) : Nphs1 (NPHS1 adhesion molecule, nephrin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0188,922,346 - 88,950,560 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,922,433 - 88,950,559 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,077,799 - 90,106,425 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,414,492 - 85,444,233 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1185,516,160 - 85,522,343 (+)NCBI
Celera180,092,938 - 80,121,035 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nphs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620460
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.