Gene: Top2a (DNA topoisomerase II alpha) Rattus norvegicus
Analyze
Symbol: Top2a
Name: DNA topoisomerase II alpha
Description: Exhibits several functions, including ATP binding activity, DNA topoisomerase type II (ATP-hydrolyzing) activity, and chromatin binding activity; involved in several processes, including DNA topological change, aging, and hindbrain development; localizes to the DNA topoisomerase complex (ATP-hydrolyzing) and nucleolus; predicted to colocalize with the centriole and nuclear chromosome; orthologous to human TOP2A (DNA topoisomerase II alpha); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha
Orthologs:
Homo sapiens (human) : TOP2A (DNA topoisomerase II alpha)  HGNC  Alliance
Mus musculus (house mouse) : Top2a (topoisomerase (DNA) II alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2a (DNA topoisomerase II alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2A (DNA topoisomerase II alpha)
Canis lupus familiaris (dog) : TOP2A (DNA topoisomerase II alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2a (DNA topoisomerase II alpha)
Sus scrofa (pig) : TOP2A (DNA topoisomerase II alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Top2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62048
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.