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Gene: Mcl1 (MCL1 apoptosis regulator, BCL2 family member) Rattus norvegicus
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Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Description: Exhibits BH domain binding activity and protein heterodimerization activity. Involved in negative regulation of apoptotic process. Predicted to localize to several cellular components, including the Bcl-2 family protein complex; cytosol; and mitochondrion. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; MCL1, BCL2 family apoptosis regulator; myeloid cell leukemia 1; myeloid cell leukemia sequence 1
Orthologs:
Homo sapiens (human) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)  HGNC  Alliance
Mus musculus (house mouse) : Mcl1 (myeloid cell leukemia sequence 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Canis lupus familiaris (dog) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcl1 (MCL1 apoptosis regulator, BCL2 family member)
Sus scrofa (pig) : MCL1 (MCL1 apoptosis regulator, BCL2 family member)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mcl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620525
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.