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Gene: Slc6a1 (solute carrier family 6 member 1) Rattus norvegicus
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Symbol: Slc6a1
Name: solute carrier family 6 member 1
Description: Exhibits gamma-aminobutyric acid:sodium symporter activity. Involved in several processes, including gamma-aminobutyric acid import; negative regulation of GABAergic synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Localizes to several cellular components, including the GABA-ergic synapse; cell surface; and integral component of synaptic membrane. Used to study brain ischemia. Biomarker of cerebral infarction; epilepsy; temporal lobe epilepsy; and withdrawal disorder. Orthologous to human SLC6A1 (solute carrier family 6 member 1); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GABA transporter protein; Gabt1; GAT-1; Gat1; sodium- and chloride-dependent GABA transporter 1; solute carrier family 6 (neurotransmitter transporter), member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Orthologs:
Homo sapiens (human) : SLC6A1 (solute carrier family 6 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a1 (solute carrier family 6 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A1 (solute carrier family 6 member 1)
Canis lupus familiaris (dog) : SLC6A1 (solute carrier family 6 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a1 (solute carrier family 6 member 1)
Sus scrofa (pig) : SLC6A1 (solute carrier family 6 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04146,258,842 - 146,292,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04209,552,452 - 209,585,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44150,249,867 - 150,265,186 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14150,494,707 - 150,510,027 (+)NCBI
Celera4136,018,664 - 136,033,983 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc6a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620533
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.