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Gene: Chek1 (checkpoint kinase 1) Rattus norvegicus
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Symbol: Chek1
Name: checkpoint kinase 1
Description: Exhibits protein kinase activity. Involved in several processes, including DNA damage induced protein phosphorylation; cellular response to caffeine; and negative regulation of DNA biosynthetic process. Predicted to colocalize with the chromosome, telomeric region. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1); PARTICIPATES IN G2/M DNA damage checkpoint pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: checkpoint kinase 1 homolog; checkpoint kinase 1 homolog (S. pombe); checkpoint kinase-1; CHK1 checkpoint homolog; CHK1 checkpoint homolog (S. pombe); serine/threonine-protein kinase Chk1
Orthologs:
Homo sapiens (human) : CHEK1 (checkpoint kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Chek1 (checkpoint kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek1 (checkpoint kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK1 (checkpoint kinase 1)
Canis lupus familiaris (dog) : CHEK1 (checkpoint kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek1 (checkpoint kinase 1)
Sus scrofa (pig) : CHEK1 (checkpoint kinase 1)
more info ...
Allele / Splice: Chek1_v2   Chek1_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0839,181,162 - 39,201,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,181,163 - 39,243,882 (-)Ensembl
Rnor_5.0839,184,020 - 39,204,446 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4837,954,322 - 37,974,748 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1837,963,088 - 37,983,514 (-)NCBI
Celera838,000,251 - 38,020,582 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Chek1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620545
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.