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Gene: Syne1 (spectrin repeat containing nuclear envelope protein 1) Rattus norvegicus
Symbol: Syne1
Name: spectrin repeat containing nuclear envelope protein 1
CRRD ID: 620546
Description: Exhibits enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mini excitatory postsynaptic potential; nervous system development; and regulation of receptor-mediated endocytosis. Localizes to several cellular components, including dendritic spine head; midbody; and nuclear membrane. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 4; autosomal recessive spinocerebellar ataxia 8; bipolar disorder; cerebellar ataxia; and muscular dystrophy. Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Also known as: CPG2; LOC102546492; Myne-1; nesprin-1; nesprin-1-like; spectrin repeat containing, nuclear envelope 1
Allele / Splice: Syne1Tn(sb-T2/Bart3)2.68Mcwi  
Genetic Models: F344-Syne1Tn(sb-T2/Bart3)2.68Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0141,844,840 - 42,086,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0141,608,287 - 41,763,591 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,608,418 - 42,077,535 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,947,742 - 43,158,478 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,803,552 - 36,269,628 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1135,805,545 - 35,961,017 (-)NCBI
Celera137,192,707 - 37,662,090 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Syne1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620546
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.