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Gene: Lpar1 (lysophosphatidic acid receptor 1) Rattus norvegicus
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Symbol: Lpar1
Name: lysophosphatidic acid receptor 1
Description: Exhibits G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; nervous system development; and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Localizes to several cellular components, including the dendrite; neuronal cell body; and plasma membrane. Predicted to colocalize with the endocytic vesicle. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Edg2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; LPA receptor 1; LPA-1; lysophosphatidic acid receptor Edg-2; MGC105279
Orthologs:
Homo sapiens (human) : LPAR1 (lysophosphatidic acid receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Lpar1 (lysophosphatidic acid receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lpar1 (lysophosphatidic acid receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LPAR1 (lysophosphatidic acid receptor 1)
Canis lupus familiaris (dog) : LPAR1 (lysophosphatidic acid receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lpar1 (lysophosphatidic acid receptor 1)
Sus scrofa (pig) : LPAR1 (lysophosphatidic acid receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0575,557,038 - 75,678,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0579,707,131 - 79,825,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,449,470 - 76,571,458 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1576,454,582 - 76,576,571 (-)NCBI
Celera572,053,065 - 72,170,436 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Lpar1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620563
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.