Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Rattus norvegicus
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Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Description: Exhibits protein tyrosine kinase activity; involved in several processes, including cellular protein modification process, gamete generation, and regulation of muscle contraction; localizes to the acrosomal vesicle, cytoplasmic side of plasma membrane, and external side of plasma membrane; used to study aplastic anemia and male infertility; biomarker of acute pancreatitis and gastroschisis; orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 2,5-hexanedione; 2-acetamidofluorene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-kit receptor tyrosine kinase; Kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; protein kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Orthologs:
Homo sapiens (human) : KIT (KIT proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Kit (KIT proto-oncogene receptor tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kit (KIT proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : KIT (KIT proto-oncogene, receptor tyrosine kinase)
more info ...
Allele / Splice: KitWs  
Genetic Models: BN-KitWs
Is Marker For: Strains:   F344-TyrCKitH/Kyo   F344-AsipATyrCKitH/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01435,072,131 - 35,149,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01434,901,860 - 34,979,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,906,043 - 34,984,819 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11434,906,042 - 34,984,819 (-)NCBI
Celera1431,837,543 - 31,913,518 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kit
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620568
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.