Gene: Nox4 (NADPH oxidase 4) Rattus norvegicus
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Symbol: Nox4
Name: NADPH oxidase 4
Description: Exhibits NAD(P)H oxidase activity; involved in several processes, including aging, cellular response to cAMP, and cellular response to gamma radiation; localizes to several cellular components, including the NADPH oxidase complex, apical plasma membrane, and intracellular organelle; colocalizes with the stress fiber; used to study hypertension; biomarker of hypertension; orthologous to human NOX4 (NADPH oxidase 4); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1
Orthologs:
Homo sapiens (human) : NOX4 (NADPH oxidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Nox4 (NADPH oxidase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nox4 (NADPH oxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NOX4 (NADPH oxidase 4)
Canis lupus familiaris (dog) : NOX4 (NADPH oxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nox4 (NADPH oxidase 4)
Sus scrofa (pig) : NOX4 (NADPH oxidase 4)
more info ...
Allele / Splice: Nox4em2Mcwi   Nox4em1Mcwi  
Genetic Models: SS-Nox4em2Ncf2em1Mcwi SS-Nox4em1Mcwi SS-Nox4em2Mcwi-/- SS-Nox4em2Mcwi-/+ SS-Nox4em2Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nox4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620600
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.