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Gene: Otof (otoferlin) Rattus norvegicus
Symbol: Otof
Name: otoferlin
Description: Predicted to have AP-2 adaptor complex binding activity and calcium ion binding activity. Involved in cochlea development. Localizes to several cellular components, including apical part of cell; basal part of cell; and endoplasmic reticulum. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9. Orthologous to human OTOF (otoferlin); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fer-1-like protein 2
Homo sapiens (human) : OTOF (otoferlin)  HGNC  Alliance
Mus musculus (house mouse) : Otof (otoferlin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Otof (otoferlin)
Pan paniscus (bonobo/pygmy chimpanzee) : OTOF (otoferlin)
Canis lupus familiaris (dog) : OTOF (otoferlin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Otof (otoferlin)
Sus scrofa (pig) : OTOF (otoferlin)
Chlorocebus sabaeus (African green monkey) : OTOF (otoferlin)
Heterocephalus glaber (naked mole-rat) : Otof (otoferlin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0627,328,343 - 27,424,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,328,406 - 27,424,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,140,727 - 37,237,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,912,607 - 26,008,137 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,003,001 - 26,007,276 (+)NCBI
Celera625,406,310 - 25,502,501 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Otof
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620646
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.