Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Map2k6 (mitogen-activated protein kinase kinase 6) Rattus norvegicus
Analyze
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Description: Exhibits MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6); PARTICIPATES IN p38 MAPK signaling pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dual specificity mitogen-activated protein kinase kinase 6; MGC93287; Mkk6
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Celera1094,024,106 - 94,137,678 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Map2k6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620666
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.