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Gene: Apln (apelin) Rattus norvegicus
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Symbol: Apln
Name: apelin
Description: Exhibits apelin receptor binding activity and identical protein binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of peptide hormone secretion; and regulation of blood circulation. Localizes to extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin); PARTICIPATES IN apelin signaling pathway; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Apel; apelin, AGTRL1 ligand; APJ endogenous ligand
Orthologs:
Homo sapiens (human) : APLN (apelin)  HGNC  Alliance
Mus musculus (house mouse) : Apln (apelin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apln (apelin)
Pan paniscus (bonobo/pygmy chimpanzee) : APLN (apelin)
Canis lupus familiaris (dog) : APLN (apelin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apln (apelin)
Sus scrofa (pig) : APLN (apelin)
Chlorocebus sabaeus (African green monkey) : APLN (apelin)
Heterocephalus glaber (naked mole-rat) : Apln (apelin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X134,856,719 - 134,866,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,856,726 - 134,866,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X134,929,116 - 134,938,607 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,387,285 - 134,396,762 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,460,719 - 134,470,195 (-)NCBI
CeleraX126,154,452 - 126,163,943 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Apln
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620672
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.