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Gene: Ltc4s (leukotriene C4 synthase) Rattus norvegicus
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Symbol: Ltc4s
Name: leukotriene C4 synthase
Description: Exhibits glutathione binding activity; leukotriene-C4 synthase activity; and protein heterodimerization activity. Involved in several processes, including cellular response to lipid; leukotriene biosynthetic process; and response to axon injury. Localizes to the intracellular membrane-bounded organelle. Biomarker of glomerulonephritis and peripheral nervous system disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LTC4S (leukotriene C4 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leukotriene-C(4) synthase; LTC4 synthase
Orthologs:
Homo sapiens (human) : LTC4S (leukotriene C4 synthase)  HGNC  Alliance
Mus musculus (house mouse) : Ltc4s (leukotriene C4 synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ltc4s (leukotriene C4 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : LTC4S (leukotriene C4 synthase)
Canis lupus familiaris (dog) : LTC4S (leukotriene C4 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ltc4s (leukotriene C4 synthase)
Sus scrofa (pig) : LTC4S (leukotriene C4 synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Celera1033,909,805 - 33,911,766 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ltc4s
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620677
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.