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Gene: Ptpro (protein tyrosine phosphatase, receptor type, O) Rattus norvegicus
Symbol: Ptpro
Name: protein tyrosine phosphatase, receptor type, O
CRRD ID: 62068
Description: Exhibits protein tyrosine phosphatase activity. Involved in negative regulation of glomerular filtration. Predicted to localize to several cellular components, including GABA-ergic synapse; integral component of postsynaptic density membrane; and lateral plasma membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
Also known as: GLEPP1; Glomerular epithelial protein 1; receptor-type protein tyrosine phosphatase D30; receptor-type tyrosine-protein phosphatase O; RPTP-BK
Homo sapiens (human) : PTPRO (protein tyrosine phosphatase receptor type O)  HGNC  Alliance
Mus musculus (house mouse) : Ptpro (protein tyrosine phosphatase, receptor type, O)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpro (protein tyrosine phosphatase receptor type O)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRO (protein tyrosine phosphatase receptor type O)
Canis lupus familiaris (dog) : PTPRO (protein tyrosine phosphatase receptor type O)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpro (protein tyrosine phosphatase receptor type O)
Sus scrofa (pig) : PTPRO (protein tyrosine phosphatase receptor type O)
Chlorocebus sabaeus (African green monkey) : PTPRO (protein tyrosine phosphatase receptor type O)
Heterocephalus glaber (naked mole-rat) : Ptpro (protein tyrosine phosphatase receptor type O)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04171,250,766 - 171,461,571 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,250,818 - 171,461,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,507,823 - 235,718,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,376,396 - 174,586,694 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14174,621,519 - 174,831,818 (+)NCBI
Celera4158,744,680 - 158,954,298 (+)NCBICelera
Cytogenetic Map4q43-q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptpro
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62068
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.