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Gene: Btnl2 (butyrophilin-like 2) Rattus norvegicus
Symbol: Btnl2
Name: butyrophilin-like 2
Description: Predicted to have signaling receptor binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; negative regulation of T cell receptor signaling pathway; and positive regulation of interleukin-2 secretion. Predicted to localize to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; Kawasaki disease; berylliosis; rheumatoid arthritis; and ulcerative colitis. Orthologous to human BTNL2 (butyrophilin like 2); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BTL-II; butyrophilin-like 2 (MHC class II associated); butyrophilin-like protein 2; Ng9
Homo sapiens (human) : BTNL2 (butyrophilin like 2)  HGNC  Alliance
Mus musculus (house mouse) : Btnl2 (butyrophilin-like 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btnl2 (butyrophilin like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BTNL2 (butyrophilin like 2)
Canis lupus familiaris (dog) : BTNL2 (butyrophilin like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btnl2 (butyrophilin like 2)
Sus scrofa (pig) : BTNL2 (butyrophilin like 2)
more info ...
Is Marker For: Strains:   DA.E3-(Btnl2-RT1-DMb)  
QTLs:   Tcs2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,140,184 - 4,156,365 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,141,878 - 4,154,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,221,727 - 6,236,503 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,613,726 - 4,625,383 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,701,740 - 4,702,792 (+)NCBI
Celera206,093,476 - 6,105,126 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Btnl2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620731
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.