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Gene: Ptprn (protein tyrosine phosphatase, receptor type, N) Rattus norvegicus
Symbol: Ptprn
Name: protein tyrosine phosphatase, receptor type, N
Description: Exhibits GTPase binding activity. Involved in several processes, including positive regulation of type B pancreatic cell proliferation; response to cAMP; and response to estrogen. Localizes to several cellular components, including axon terminus; neuronal cell body; and secretory granule. Colocalizes with Golgi apparatus; endosome; and plasma membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N); PARTICIPATES IN type 1 diabetes mellitus pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: 105 kDa islet cell antigen; BEM-3; brain-enriched membrane-associated protein tyrosine phosphatase; Ia-2; ICA105; ICA512; PTP IA-2; PTPLP; R-PTP-N; receptor-type tyrosine-protein phosphatase-like N
Homo sapiens (human) : PTPRN (protein tyrosine phosphatase receptor type N)  HGNC  Alliance
Mus musculus (house mouse) : Ptprn (protein tyrosine phosphatase, receptor type, N)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprn (protein tyrosine phosphatase receptor type N)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRN (protein tyrosine phosphatase receptor type N)
Canis lupus familiaris (dog) : PTPRN (protein tyrosine phosphatase receptor type N)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprn (protein tyrosine phosphatase receptor type N)
Sus scrofa (pig) : PTPRN (protein tyrosine phosphatase receptor type N)
Chlorocebus sabaeus (African green monkey) : PTPRN (protein tyrosine phosphatase receptor type N)
Heterocephalus glaber (naked mole-rat) : Ptprn (protein tyrosine phosphatase receptor type N)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0982,446,626 - 82,462,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,446,633 - 82,461,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,215,889 - 82,231,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,528,095 - 74,542,756 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1974,675,076 - 74,689,738 (-)NCBI
Celera974,311,913 - 74,326,515 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptprn
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620777
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.