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Gene: Lat (linker for activation of T cells) Rattus norvegicus
Symbol: Lat
Name: linker for activation of T cells
Description: Predicted to have SH3/SH2 adaptor activity and protein kinase binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; intracellular signal transduction; and lymphocyte homeostasis. Predicted to localize to several cellular components, including COP9 signalosome; Golgi apparatus; and immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LAT (linker for activation of T cells); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; Fc gamma receptor mediated signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine.
Type: protein-coding
Also known as: 36 kDa phospho-tyrosine adapter protein; linker for activation of T-cells family member 1; MGC108666; p36-38; pp36
Homo sapiens (human) : LAT (linker for activation of T cells)  HGNC  Alliance
Mus musculus (house mouse) : Lat (linker for activation of T cells)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lat (linker for activation of T cells)
Pan paniscus (bonobo/pygmy chimpanzee) : LAT (linker for activation of T cells)
Canis lupus familiaris (dog) : LAT (linker for activation of T cells)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lat (linker for activation of T cells)
Sus scrofa (pig) : LAT (linker for activation of T cells)
Chlorocebus sabaeus (African green monkey) : LAT (linker for activation of T cells)
Heterocephalus glaber (naked mole-rat) : Lat (linker for activation of T cells)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01197,765,644 - 197,770,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1197,765,644 - 197,770,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,747,718 - 204,752,745 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,450,155 - 185,455,180 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,600,035 - 185,605,061 (-)NCBI
Celera1178,597,456 - 178,602,481 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lat
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620802
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.