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Gene: Lbr (lamin B receptor) Rattus norvegicus
Symbol: Lbr
Name: lamin B receptor
Description: Exhibits chaperone binding activity and nuclear localization sequence binding activity. Involved in mitotic cell cycle. Localizes to cytoplasm and nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cirrhosis. Orthologous to human LBR (lamin B receptor); PARTICIPATES IN cholesterol biosynthetic pathway; histone modification pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; ammonium chloride.
Type: protein-coding
Also known as: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; delta(14)-sterol reductase; delta(14)-sterol reductase LBR; delta-14-SR; integral nuclear envelope inner membrane protein; lamin-B receptor; Nbp60; sterol C14-reductase
Homo sapiens (human) : LBR (lamin B receptor)  HGNC  Alliance
Mus musculus (house mouse) : Lbr (lamin B receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lbr (lamin B receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LBR (lamin B receptor)
Canis lupus familiaris (dog) : LBR (lamin B receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lbr (lamin B receptor)
Sus scrofa (pig) : LBR (lamin B receptor)
Chlorocebus sabaeus (African green monkey) : LBR (lamin B receptor)
Heterocephalus glaber (naked mole-rat) : Lbr (lamin B receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.013100,431,390 - 100,450,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013106,629,770 - 106,648,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41397,814,439 - 97,834,860 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11398,003,374 - 98,023,796 (-)NCBI
Celera1393,078,084 - 93,097,481 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lbr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620813
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.