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Gene: Eif2b1 (eukaryotic translation initiation factor 2B subunit alpha) Rattus norvegicus
Symbol: Eif2b1
Name: eukaryotic translation initiation factor 2B subunit alpha
Description: Exhibits GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to glucose; and translational initiation. Localizes to eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eIF-2a; eIF-2B GDP-GTP exchange factor subunit alpha; eIF-2Balpha; eukaryotic translation initiation factor 2B subunit 1; eukaryotic translation initiation factor 2B subunit 1 alpha; eukaryotic translation initiation factor 2B, subunit 1 alpha; GTP-exchange protein; translation initiation factor eIF-2B alpha-subunit; translation initiation factor eIF-2B subunit alpha
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01237,444,136 - 37,452,391 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,444,072 - 37,465,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01239,315,146 - 39,323,401 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,138,323 - 33,146,596 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1233,715,011 - 33,723,266 (+)NCBICelera
Cytogenetic Map12q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Eif2b1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620819
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.