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Gene: Nppc (natriuretic peptide C) Rattus norvegicus
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Symbol: Nppc
Name: natriuretic peptide C
Description: Exhibits hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Localizes to extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 3',5'-cyclic GMP; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-type natriuretic peptide; natriuretic peptide precursor C; natriuretic peptide precursor type C
Orthologs:
Homo sapiens (human) : NPPC (natriuretic peptide C)  HGNC  Alliance
Mus musculus (house mouse) : Nppc (natriuretic peptide type C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppc (natriuretic peptide C)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPC (natriuretic peptide C)
Canis lupus familiaris (dog) : NPPC (natriuretic peptide C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppc (natriuretic peptide C)
Sus scrofa (pig) : NPPC (natriuretic peptide C)
Chlorocebus sabaeus (African green monkey) : NPPC (natriuretic peptide C)
Heterocephalus glaber (naked mole-rat) : Nppc (natriuretic peptide C)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nppc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620850
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.