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Gene: F2rl1 (F2R like trypsin receptor 1) Rattus norvegicus
Symbol: F2rl1
Name: F2R like trypsin receptor 1
Description: Predicted to have G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in positive regulation of blood vessel diameter and positive regulation of glomerular filtration. Predicted to localize to early endosome; integral component of plasma membrane; and pseudopodium. Biomarker of lung disease. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; sleeping sickness pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; Par-2; Par2; proteinase-activated receptor 2; Proteinase-activated receptor-2 G protein-coupled receptor 11; Proteinase-activated receptor-2, G protein-coupled receptor 11; thrombin receptor-like 1
Homo sapiens (human) : F2RL1 (F2R like trypsin receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : F2rl1 (coagulation factor II (thrombin) receptor-like 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2rl1 (F2R like trypsin receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : F2RL1 (F2R like trypsin receptor 1)
Canis lupus familiaris (dog) : F2RL1 (F2R like trypsin receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2rl1 (F2R like trypsin receptor 1)
Sus scrofa (pig) : F2RL1 (F2R like trypsin receptor 1)
Chlorocebus sabaeus (African green monkey) : F2RL1 (F2R like trypsin receptor 1)
Heterocephalus glaber (naked mole-rat) : F2rl1 (F2R like trypsin receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on F2rl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620866
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.