Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nucb2 (nucleobindin 2) Rattus norvegicus
Analyze
Symbol: Nucb2
Name: nucleobindin 2
Description: Exhibits tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Localizes to the Golgi medial cisterna and extracellular space. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2); INTERACTS WITH (RS)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA-binding protein NEFA; Nefa; NEFA precursor; nesfatin-1; nucleobindin-2; p54; prepronefastin; prepronesfatin
Orthologs:
Homo sapiens (human) : NUCB2 (nucleobindin 2)  HGNC  Alliance
Mus musculus (house mouse) : Nucb2 (nucleobindin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nucb2 (nucleobindin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NUCB2 (nucleobindin 2)
Canis lupus familiaris (dog) : NUCB2 (nucleobindin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nucb2 (nucleobindin 2)
Sus scrofa (pig) : NUCB2 (nucleobindin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01185,106,773 - 185,143,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01192,078,545 - 192,115,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,605,677 - 174,642,111 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11174,744,922 - 174,781,355 (+)NCBI
Celera1168,570,763 - 168,607,089 (+)NCBICelera
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nucb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620888
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.