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Gene: Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) Rattus norvegicus
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Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Description: Exhibits 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphorylation. Localizes to the brush border membrane and phosphatidylinositol 3-kinase complex. Used to study thrombosis. Human ortholog(s) of this gene implicated in glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; bexarotene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; ptdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Celera899,000,434 - 99,072,100 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pik3cb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620917
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.