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Gene: Lss (lanosterol synthase) Rattus norvegicus
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Symbol: Lss
Name: lanosterol synthase
Description: Exhibits lanosterol synthase activity. Involved in cholesterol biosynthetic process. Localizes to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in cataract 44 and hypotrichosis 14. Orthologous to human LSS (lanosterol synthase); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2,3-epoxysqualene--lanosterol cyclase; 2,3-oxidosqualene: lanosterol cyclase; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); OSC; oxidosqualene--lanosterol cyclase
Orthologs:
Homo sapiens (human) : LSS (lanosterol synthase)  HGNC  Alliance
Mus musculus (house mouse) : Lss (lanosterol synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lss (lanosterol synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : LSS (lanosterol synthase)
Canis lupus familiaris (dog) : LSS (lanosterol synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lss (lanosterol synthase)
Sus scrofa (pig) : LSS (lanosterol synthase)
more info ...
Allele / Splice: Lssem2Mcwi  
Genetic Models: SS-Lssem2Mcwi
Is Marker For: Strains:   SCR/Sscr  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02012,844,522 - 12,870,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,842,884 - 12,870,497 (-)Ensembl
Rnor_5.02015,000,298 - 15,027,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02015,337,114 - 15,338,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,507,575 - 12,534,612 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12012,507,801 - 12,534,839 (-)NCBI
Celera2013,590,952 - 13,616,816 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lss
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620955
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.