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Gene: Pde2a (phosphodiesterase 2A) Rattus norvegicus
Symbol: Pde2a
Name: phosphodiesterase 2A
CRRD ID: 620965
Description: Exhibits identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP-mediated signaling; and response to hydrogen sulfide. Localizes to several cellular components, including hippocampal mossy fiber; membrane raft; and mitochondrion. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; Pde2; Pde2a2; phosphodiesterase 2A, cGMP-stimulated
Homo sapiens (human) : PDE2A (phosphodiesterase 2A)  HGNC  Alliance
Mus musculus (house mouse) : Pde2a (phosphodiesterase 2A, cGMP-stimulated)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde2a (phosphodiesterase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE2A (phosphodiesterase 2A)
Canis lupus familiaris (dog) : PDE2A (phosphodiesterase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde2a (phosphodiesterase 2A)
Sus scrofa (pig) : PDE2A (phosphodiesterase 2A)
Chlorocebus sabaeus (African green monkey) : PDE2A (phosphodiesterase 2A)
Heterocephalus glaber (naked mole-rat) : Pde2a (phosphodiesterase 2A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pde2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620965
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.