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Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1) Rattus norvegicus
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Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Description: Exhibits several functions, including JUN kinase kinase kinase activity; enzyme binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including cellular protein modification process; negative regulation of actin filament bundle assembly; and positive regulation of viral transcription. Localizes to the cytoplasm and membrane. Colocalizes with the cytoskeleton. Human ortholog(s) of this gene implicated in 46 XY gonadal dysgenesis and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Map3k1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620966
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.