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Gene: Map3k8 (mitogen-activated protein kinase kinase kinase 8) Rattus norvegicus
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Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Description: Exhibits MAP kinase kinase kinase activity. Predicted to be involved in activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to the cytosol. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D17TPL2; serine/threonine kinase (Tpl-2); Tpl-2; Tpl2; tumor progression locus 2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01756,109,403 - 56,129,925 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01754,146,364 - 54,166,886 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41761,910,179 - 61,930,459 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11761,921,011 - 61,941,292 (+)NCBI
Celera1749,376,490 - 49,396,770 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Map3k8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620969
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.