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Gene: Pde5a (phosphodiesterase 5A) Rattus norvegicus
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Symbol: Pde5a
Name: phosphodiesterase 5A
Description: Exhibits 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including regulation of blood vessel diameter; response to testosterone; and short-term memory. Localizes to the cytosol. Used to study artery disease (multiple); impotence (multiple); and primary biliary cirrhosis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5A2; phosphodiesterase 5A, cGMP-specific; phosphodiesterase type 5
Orthologs:
Homo sapiens (human) : PDE5A (phosphodiesterase 5A)  HGNC  Alliance
Mus musculus (house mouse) : Pde5a (phosphodiesterase 5A, cGMP-specific)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde5a (phosphodiesterase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE5A (phosphodiesterase 5A)
Canis lupus familiaris (dog) : PDE5A (phosphodiesterase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde5a (phosphodiesterase 5A)
Sus scrofa (pig) : PDE5A (phosphodiesterase 5A)
more info ...
Allele / Splice: Pde5aTn(sb-T2/Bart3)2.144Mcwi  
Genetic Models: F344-Pde5aTn(sb-T2/Bart3)2.144Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02226,899,604 - 227,044,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02246,260,843 - 246,406,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,410,394 - 219,550,910 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12219,373,455 - 219,513,972 (+)NCBI
Celera2203,287,460 - 203,425,472 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Pde5a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620995
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.