Gene: Shank1 (SH3 and multiple ankyrin repeat domains 1) Rattus norvegicus
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Symbol: Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Description: Exhibits several functions, including GKAP/Homer scaffold activity, protein domain specific binding activity, and signaling receptor binding activity; involved in positive regulation of dendritic spine development, protein-containing complex assembly, and synapse maturation; localizes to the dendritic spine and postsynaptic membrane; colocalizes with the NMDA selective glutamate receptor complex; orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH ammonium chloride; androgen antagonist; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; Shank1a; somatostatin receptor-interacting protein; SPANK-1; Spank1; SSTR-interacting protein; Sstrip; synamon
Orthologs:
Homo sapiens (human) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)  HGNC  Alliance
Mus musculus (house mouse) : Shank1 (SH3 and multiple ankyrin repeat domains 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Canis lupus familiaris (dog) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Sus scrofa (pig) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01100,297,137 - 100,344,377 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01101,362,243 - 101,410,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,791,887 - 94,840,584 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1194,872,463 - 94,918,294 (+)NCBI
Celera189,071,051 - 89,118,344 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Shank1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621011
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.