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Gene: Nr0b2 (nuclear receptor subfamily 0, group B, member 2) Rattus norvegicus
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Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
CRRD ID: 621032
Description: Exhibits peroxisome proliferator activated receptor binding activity; retinoid X receptor binding activity; and thyroid hormone receptor binding activity. Involved in several processes, including animal organ regeneration; bile acid and bile salt transport; and positive regulation of insulin secretion. Localizes to protein-containing complex. Biomarker of alcoholic hepatitis; diabetes mellitus; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; Shp; small heterodimer partner homologue
Orthologs:
Homo sapiens (human) : NR0B2 (nuclear receptor subfamily 0 group B member 2)  HGNC  Alliance
Mus musculus (house mouse) : Nr0b2 (nuclear receptor subfamily 0, group B, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Canis lupus familiaris (dog) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Sus scrofa (pig) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Chlorocebus sabaeus (African green monkey) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Heterocephalus glaber (naked mole-rat) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
more info ...
Allele / Splice: Nr0b2m1Mcwi  
Genetic Models: FHH-Nr0b2m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05151,776,004 - 151,779,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,776,004 - 151,779,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,465,275 - 155,468,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,524,685 - 151,528,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,534,723 - 151,538,039 (-)NCBI
Celera5144,199,860 - 144,203,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map5977.8RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr0b2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621032
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.