Gene: Socs3 (suppressor of cytokine signaling 3) Rattus norvegicus
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Symbol: Socs3
Name: suppressor of cytokine signaling 3
Description: Predicted to have phosphotyrosine residue binding activity; involved in several processes, including aging, animal organ regeneration, and response to steroid hormone; localizes to the cytoplasm; biomarker of obesity, status epilepticus, and type 2 diabetes mellitus; orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-nicotine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; Socs-3; Ssi-3
Orthologs:
Homo sapiens (human) : SOCS3 (suppressor of cytokine signaling 3)  HGNC  Alliance
Mus musculus (house mouse) : Socs3 (suppressor of cytokine signaling 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Socs3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621087
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.