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Gene: Syngap1 (synaptic Ras GTPase activating protein 1) Rattus norvegicus
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Symbol: Syngap1
Name: synaptic Ras GTPase activating protein 1
Description: Exhibits GTPase activator activity and protein kinase binding activity. Involved in negative regulation of Ras protein signal transduction and regulation of synaptic plasticity. Localizes to the glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 5. Orthologous to human SYNGAP1 (synaptic Ras GTPase activating protein 1); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: neuronal RasGAP; p135 SynGAP; ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase-activating protein 1; synaptic Ras-GAP 1; Syngap
Orthologs:
Homo sapiens (human) : SYNGAP1 (synaptic Ras GTPase activating protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Syngap1 (synaptic Ras GTPase activating protein 1 homolog (rat))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syngap1 (synaptic Ras GTPase activating protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Canis lupus familiaris (dog) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syngap1 (synaptic Ras GTPase activating protein 1)
Sus scrofa (pig) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0205,535,434 - 5,564,657 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,594,614 - 7,623,865 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,178,523 - 5,208,449 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,191,049 - 5,207,973 (+)NCBI
Celera206,608,780 - 6,637,810 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Syngap1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621090
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.