Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdk4 (cyclin-dependent kinase 4) Rattus norvegicus
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell size; response to hyperoxia; and response to testosterone. Localizes to nucleus and perinuclear region of cytoplasm. Predicted to colocalize with bicellular tight junction. Biomarker of pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: cell division protein kinase 4; LOC100362034; PSK-J3
Homo sapiens (human) : CDK4 (cyclin dependent kinase 4)  HGNC  Alliance
Mus musculus (house mouse) : Cdk4 (cyclin-dependent kinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk4 (cyclin dependent kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK4 (cyclin dependent kinase 4)
Canis lupus familiaris (dog) : CDK4 (cyclin dependent kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk4 (cyclin dependent kinase 4)
Sus scrofa (pig) : CDK4 (cyclin dependent kinase 4)
Chlorocebus sabaeus (African green monkey) : CDK4 (cyclin dependent kinase 4)
Heterocephalus glaber (naked mole-rat) : Cdk4 (cyclin dependent kinase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0770,345,971 - 70,352,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,349,863 - 70,352,418 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,527,545 - 70,530,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1767,037,674 - 67,039,905 (+)NCBI
Celera760,029,956 - 60,032,798 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cdk4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621120
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.