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Gene: Map4k3 (mitogen-activated protein kinase kinase kinase kinase 3) Rattus norvegicus
Symbol: Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Description: Exhibits SH3 domain binding activity. Predicted to be involved in several processes, including response to tumor necrosis factor; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to the cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.063,276,732 - 3,444,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.063,247,181 - 3,414,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,473,694 - 3,642,461 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.163,475,028 - 3,642,293 (-)NCBI
Celera613,956,412 - 14,123,546 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map4k3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621280
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.