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Gene: Twist2 (twist family bHLH transcription factor 2) Rattus norvegicus
Symbol: Twist2
Name: twist family bHLH transcription factor 2
Description: Predicted to have several functions, including DNA-binding transcription factor activity; chromatin binding activity; and transcription factor binding activity. Involved in negative regulation of apoptotic process. Predicted to localize to cytoplasm; nuclear lumen; and transcription factor complex. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dermo-1 protein; Dermo1; twist basic helix-loop-helix transcription factor 2; twist homolog 2; twist homolog 2 (Drosophila); twist-related protein 2
Homo sapiens (human) : TWIST2 (twist family bHLH transcription factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Twist2 (twist basic helix-loop-helix transcription factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Twist2 (twist family bHLH transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TWIST2 (twist family bHLH transcription factor 2)
Canis lupus familiaris (dog) : TWIST2 (twist family bHLH transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Twist2 (twist family bHLH transcription factor 2)
Sus scrofa (pig) : TWIST2 (twist family bHLH transcription factor 2)
Chlorocebus sabaeus (African green monkey) : TWIST2 (twist family bHLH transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Twist2 (twist family bHLH transcription factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0998,924,134 - 98,968,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,924,134 - 98,968,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,599,201 - 98,642,827 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4991,016,450 - 91,058,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1991,221,218 - 91,263,067 (+)NCBI
Celera989,915,377 - 89,958,630 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Twist2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621286
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.