Gene: Thbd (thrombomodulin) Rattus norvegicus
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Symbol: Thbd
Name: thrombomodulin
Description: Predicted to have calcium ion binding activity and transmembrane signaling receptor activity; involved in response to X-ray, response to cAMP, and response to lipopolysaccharide; localizes to the apicolateral plasma membrane, extracellular space, and vacuolar membrane; used to study acute kidney failure; biomarker of adult respiratory distress syndrome, hypertension, ischemia, and type 2 diabetes mellitus; orthologous to human THBD (thrombomodulin); PARTICIPATES IN protein C anticoagulant pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: thrombomdulin
Orthologs:
Homo sapiens (human) : THBD (thrombomodulin)  HGNC  Alliance
Mus musculus (house mouse) : Thbd (thrombomodulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thbd (thrombomodulin)
Pan paniscus (bonobo/pygmy chimpanzee) : THBD (thrombomodulin)
Canis lupus familiaris (dog) : THBD (thrombomodulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thbd (thrombomodulin)
Sus scrofa (pig) : THBD (thrombomodulin)
more info ...
Allele / Splice: Thbdm1Mcwi  
Genetic Models: SS-Thbdm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03142,748,673 - 142,752,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03149,159,895 - 149,163,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,158,955 - 137,162,607 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13137,064,528 - 137,068,180 (-)NCBI
Celera3134,707,185 - 134,710,838 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Thbd
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621299
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.