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Gene: Mmp3 (matrix metallopeptidase 3) Rattus norvegicus
Symbol: Mmp3
Name: matrix metallopeptidase 3
Description: Predicted to have metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Localizes to several cellular components, including cell body; dendrite; and extracellular space. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal failure; esophagus adenocarcinoma; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3); PARTICIPATES IN rheumatoid arthritis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: matrix metalloproteinase 3; matrix metalloproteinase-3; MMP-3; PTR1 protein; SL-1; stromelysin-1; transin-1
Homo sapiens (human) : MMP3 (matrix metallopeptidase 3)  HGNC  Alliance
Mus musculus (house mouse) : Mmp3 (matrix metallopeptidase 3)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : MMP3 (matrix metallopeptidase 3)
Canis lupus familiaris (dog) : MMP3 (matrix metallopeptidase 3 (stromelysin 1, progelatinase))
Sus scrofa (pig) : MMP3 (matrix metallopeptidase 3)
Chlorocebus sabaeus (African green monkey) : MMP3 (matrix metallopeptidase 3)
Heterocephalus glaber (naked mole-rat) : Mmp3 (matrix metallopeptidase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mmp3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621317
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.