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Gene: Rpe65 (retinoid isomerohydrolase RPE65) Rattus norvegicus
Symbol: Rpe65
Name: retinoid isomerohydrolase RPE65
CRRD ID: 621396
Description: Exhibits all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Localizes to cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; and retinitis pigmentosa 20. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65); PARTICIPATES IN retinoid cycle metabolic pathway; altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65; retinal pigment epithelium 65-like; retinal pigment epithelium, 65 kDa; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65; retinoid isomerohydrolase; retinol isomerase; RPE65, retinoid isomerohydrolase
Homo sapiens (human) : RPE65 (retinoid isomerohydrolase RPE65)  HGNC  Alliance
Mus musculus (house mouse) : Rpe65 (retinal pigment epithelium 65)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rpe65 (retinoid isomerohydrolase RPE65)
Pan paniscus (bonobo/pygmy chimpanzee) : RPE65 (retinoid isomerohydrolase RPE65)
Canis lupus familiaris (dog) : RPE65 (retinoid isomerohydrolase RPE65)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rpe65 (retinoid isomerohydrolase RPE65)
Sus scrofa (pig) : RPE65 (retinoid isomerohydrolase RPE65)
Chlorocebus sabaeus (African green monkey) : RPE65 (retinoid isomerohydrolase RPE65)
Heterocephalus glaber (naked mole-rat) : Rpe65 (retinoid isomerohydrolase RPE65)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02266,141,581 - 266,169,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2266,141,581 - 266,169,197 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02284,774,159 - 284,804,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.12257,860,998 - 257,893,921 (+)NCBI
Celera2240,512,281 - 240,537,640 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Rpe65
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621396
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.