Symbol:
Cdc42bpa
Name:
CDC42 binding protein kinase alpha
Description:
Exhibits several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including actin cytoskeleton organization; protein phosphorylation; and regulation of small GTPase mediated signal transduction. Localizes to the actomyosin; cell leading edge; and cell-cell junction. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha); INTERACTS WITH 1,1-dichloroethene; ammonium chloride; beta-naphthoflavone.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
CDC42-binding protein kinase alpha; Mrck; MRCK alpha; myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; Pk428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; serine/threonine-protein kinase MRCK alpha
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CDC42BPA (CDC42 binding protein kinase alpha) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Cdc42bpa (CDC42 binding protein kinase alpha) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cdc42bpa (CDC42 binding protein kinase alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CDC42BPA (CDC42 binding protein kinase alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CDC42BPA (CDC42 binding protein kinase alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cdc42bpa (CDC42 binding protein kinase alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CDC42BPA (CDC42 binding protein kinase alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CDC42BPG (CDC42 binding protein kinase gamma) HGNC
OrthoMCL
Homo sapiens (human):
CDC42BPB (CDC42 binding protein kinase beta) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Cdc42bpa (CDC42 binding protein kinase alpha)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CDC42BPA (CDC42 binding protein kinase alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cdc42bpaa (CDC42 binding protein kinase alpha (DMPK-like) a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
gek
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
mrck-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 98,231,326 - 98,447,762 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 98,231,326 - 98,447,762 (+) Ensembl Rnor_5.0 13 103,238,053 - 103,453,991 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 95,640,342 - 95,865,501 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 95,829,277 - 96,054,435 (+) NCBI Celera 13 91,234,788 - 91,448,806 (+) NCBI Celera Cytogenetic Map 13 q26 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of CDC42BPA protein CTD PMID:14565772 17alpha-ethynylestradiol affects expression ISO RGD:733007 6480464 Ethinyl Estradiol affects the expression of CDC42BPA mRNA CTD PMID:17555576 17beta-estradiol multiple interactions ISO RGD:1351605 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA CTD PMID:20823114 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733007 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:733007 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733007 6480464 Tetrachlorodibenzodioxin results in increased expression of CDC42BPA mRNA CTD PMID:21354282 3,4-methylenedioxymethamphetamine increases expression ISO RGD:733007 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CDC42BPA mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:733007 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CDC42BPA mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation ISO RGD:733007 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of CDC42BPA promoter CTD PMID:26251327 5-azacytidine decreases expression ISO RGD:1351605 6480464 Azacitidine results in decreased expression of CDC42BPA mRNA CTD PMID:20823114 aflatoxin B1 increases methylation ISO RGD:1351605 6480464 Aflatoxin B1 results in increased methylation of CDC42BPA intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CDC42BPA mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:1351605 6480464 Antirheumatic Agents results in increased expression of CDC42BPA mRNA CTD PMID:24449571 Aroclor 1254 decreases expression ISO RGD:733007 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42BPA mRNA CTD PMID:23650126 arsane affects methylation ISO RGD:1351605 6480464 Arsenic affects the methylation of CDC42BPA gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1351605 6480464 Arsenic affects the methylation of CDC42BPA gene CTD PMID:25304211 arsenite(3-) increases methylation ISO RGD:1351605 6480464 arsenite results in increased methylation of CDC42BPA promoter CTD PMID:23974009 arsenous acid increases expression ISO RGD:1351605 6480464 Arsenic Trioxide results in increased expression of CDC42BPA mRNA CTD PMID:15761015 , PMID:19128835 atrazine decreases expression ISO RGD:1351605 6480464 Atrazine results in decreased expression of CDC42BPA mRNA CTD PMID:22378314 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNA CTD PMID:18164116 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CDC42BPA mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of CDC42BPA gene CTD PMID:28505145 bucladesine multiple interactions ISO RGD:1351605 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA CTD PMID:20823114 butanal decreases expression ISO RGD:1351605 6480464 butyraldehyde results in decreased expression of CDC42BPA mRNA CTD PMID:26079696 carbamazepine affects expression ISO RGD:1351605 6480464 Carbamazepine affects the expression of CDC42BPA mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:733007 6480464 Nanotubes, Carbon analog results in decreased expression of CDC42BPA mRNA, Nanotubes, Carbon results in decreased expression of CDC42BPA mRNA CTD PMID:25554681 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of CDC42BPA mRNA CTD PMID:23125180 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of CDC42BPA mRNA CTD PMID:18668222 cobalt dichloride decreases expression ISO RGD:1351605 6480464 cobaltous chloride results in decreased expression of CDC42BPA mRNA CTD PMID:19320972 copper(II) sulfate increases expression ISO RGD:1351605 6480464 Copper Sulfate results in increased expression of CDC42BPA mRNA CTD PMID:19549813 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of CDC42BPA mRNA CTD PMID:23640034 diarsenic trioxide increases expression ISO RGD:1351605 6480464 Arsenic Trioxide results in increased expression of CDC42BPA mRNA CTD PMID:15761015 , PMID:19128835 dibutyl phthalate decreases expression ISO RGD:733007 6480464 Dibutyl Phthalate results in decreased expression of CDC42BPA mRNA CTD PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of CDC42BPA mRNA CTD PMID:21266533 dorsomorphin multiple interactions ISO RGD:1351605 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1351605 6480464 Doxorubicin results in decreased expression of CDC42BPA mRNA CTD PMID:29803840 elemental selenium multiple interactions ISO RGD:1351605 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 elemental selenium decreases expression ISO RGD:1351605 6480464 Selenium results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 endosulfan increases expression ISO RGD:1351605 6480464 Endosulfan results in increased expression of CDC42BPA mRNA CTD PMID:26615145 ethanol decreases expression ISO RGD:733007 6480464 Ethanol results in decreased expression of CDC42BPA mRNA CTD PMID:29018328 ethanol affects splicing ISO RGD:733007 6480464 Ethanol affects the splicing of CDC42BPA mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:1351605 6480464 Ethyl Methanesulfonate results in increased expression of CDC42BPA mRNA CTD PMID:23649840 fonofos decreases methylation ISO RGD:1351605 6480464 Fonofos results in decreased methylation of CDC42BPA promoter CTD PMID:22847954 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of CDC42BPA gene CTD PMID:31011160 irinotecan decreases expression ISO RGD:1351605 6480464 Irinotecan analog results in decreased expression of CDC42BPA mRNA CTD PMID:18927307 medroxyprogesterone acetate multiple interactions ISO RGD:1351605 6480464 [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA CTD PMID:20823114 methyl methanesulfonate increases expression ISO RGD:1351605 6480464 Methyl Methanesulfonate results in increased expression of CDC42BPA mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNA CTD PMID:18164116 p-chloromercuribenzoic acid increases expression ISO RGD:1351605 6480464 p-Chloromercuribenzoic Acid results in increased expression of CDC42BPA mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1351605 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA CTD PMID:27188386 parathion decreases methylation ISO RGD:1351605 6480464 Parathion results in decreased methylation of CDC42BPA promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1351605 6480464 perfluorooctane sulfonic acid results in decreased expression of CDC42BPA mRNA CTD PMID:27153767 pirinixic acid multiple interactions ISO RGD:1351605 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDC42BPA mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:733007 6480464 pirinixic acid results in increased expression of CDC42BPA mRNA CTD PMID:18301758 potassium chromate decreases expression ISO RGD:1351605 6480464 potassium chromate(VI) results in decreased expression of CDC42BPA mRNA CTD PMID:22714537 SB 431542 multiple interactions ISO RGD:1351605 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA CTD PMID:27188386 selenium atom multiple interactions ISO RGD:1351605 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 selenium atom decreases expression ISO RGD:1351605 6480464 Selenium results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 succimer multiple interactions ISO RGD:1351605 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDC42BPA mRNA CTD PMID:26378955 terbufos decreases methylation ISO RGD:1351605 6480464 terbufos results in decreased methylation of CDC42BPA promoter CTD PMID:22847954 urethane increases expression ISO RGD:1351605 6480464 Urethane results in increased expression of CDC42BPA mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:1351605 6480464 Valproic Acid results in decreased expression of CDC42BPA mRNA CTD PMID:23179753 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of CDC42BPA mRNA CTD PMID:29427782 vitamin E multiple interactions ISO RGD:1351605 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 vitamin E increases expression ISO RGD:1351605 6480464 Vitamin E results in increased expression of CDC42BPA mRNA CTD PMID:19244175 vitamin E decreases expression ISO RGD:1351605 6480464 Vitamin E results in decreased expression of CDC42BPA mRNA CTD PMID:19244175 vorinostat decreases expression ISO RGD:1351605 6480464 vorinostat results in decreased expression of CDC42BPA mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
