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Gene: Aldh5a1 (aldehyde dehydrogenase 5 family, member A1) Rattus norvegicus
Symbol: Aldh5a1
Name: aldehyde dehydrogenase 5 family, member A1
Description: Exhibits NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in oxidation-reduction process and succinate metabolic process. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH (+)-schisandrin B; acetaldehyde; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Ssadh; succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase
Homo sapiens (human) : ALDH5A1 (aldehyde dehydrogenase 5 family member A1)  HGNC  Alliance
Mus musculus (house mouse) : Aldh5a1 (aldhehyde dehydrogenase family 5, subfamily A1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh5a1 (aldehyde dehydrogenase 5 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH5A1 (aldehyde dehydrogenase 5 family member A1)
Canis lupus familiaris (dog) : ALDH5A1 (aldehyde dehydrogenase 5 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh5a1 (aldehyde dehydrogenase 5 family member A1)
Sus scrofa (pig) : ALDH5A1 (aldehyde dehydrogenase 5 family member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01742,133,076 - 42,159,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,133,076 - 42,159,413 (+)Ensembl
Rnor_5.01744,000,875 - 44,027,212 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,193,407 - 47,216,499 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11747,196,722 - 47,219,340 (+)NCBI
Celera1739,769,869 - 39,796,199 (+)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aldh5a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621422
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.