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Gene: Ptch1 (patched 1) Rattus norvegicus
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Symbol: Ptch1
Name: patched 1
Description: Predicted to have several functions, including cholesterol binding activity; cyclin binding activity; and signaling receptor binding activity. Involved in several processes, including commissural neuron axon guidance; gland development; and response to estradiol. Localizes to growth cone; nucleus; and postsynaptic density. Predicted to colocalize with Golgi apparatus. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1); PARTICIPATES IN altered Hedgehog signaling pathway; glypican signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC290961; patched (Drosophila) homolog; patched homolog 1; patched homolog 1 (Drosophila); patched homolog 2; Ptch; Ptch2
Orthologs:
Homo sapiens (human) : PTCH1 (patched 1)  HGNC  Alliance
Mus musculus (house mouse) : Ptch1 (patched 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptch1 (patched 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTCH1 (patched 1)
Canis lupus familiaris (dog) : PTCH1 (patched 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptch1 (patched 1)
Sus scrofa (pig) : PTCH1 (patched 1)
Chlorocebus sabaeus (African green monkey) : PTCH1 (patched 1)
Heterocephalus glaber (naked mole-rat) : Ptch1 (patched 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0171,032,242 - 1,085,885 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,029,048 - 1,093,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,025,798 - 1,079,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,088,234 - 7,142,459 (+)NCBIRGSC3.4rn4RGSC3.4
Celera17917,710 - 971,638 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ptch1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621425
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.