Gene: Nefl (neurofilament light) Rattus norvegicus
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Symbol: Nefl
Name: neurofilament light
Description: Exhibits phospholipase binding activity, protein domain specific binding activity, and protein heterodimerization activity; involved in several processes, including animal organ development, intermediate filament cytoskeleton organization, and protein polymerization; localizes to the growth cone and neurofilament; used to study congenital hypothyroidism; biomarker of hypothyroidism, mental depression, sciatic neuropathy, and transient cerebral ischemia; orthologous to human NEFL (neurofilament light); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 2,5-hexanedione; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 68 kDa neurofilament protein; 68kDa neurofilament; neurofilament light polypeptide; neurofilament triplet L protein; neurofilament, light polypeptide; NF-L; NF68; Nfl
Orthologs:
Homo sapiens (human) : NEFL (neurofilament light)  HGNC  Alliance
Mus musculus (house mouse) : Nefl (neurofilament, light polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefl (neurofilament light)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFL (neurofilament light)
Canis lupus familiaris (dog) : NEFL (neurofilament light)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefl (neurofilament light)
Sus scrofa (pig) : NEFL (neurofilament light)
more info ...
Is Marker For: QTLs:   MAMTS3_H  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01544,799,378 - 44,803,251 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01546,793,526 - 46,797,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,636,303 - 47,640,176 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,652,082 - 47,655,956 (+)NCBI
Celera1541,961,053 - 41,964,926 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nefl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621458
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.