Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cdc25a (cell division cycle 25A) Rattus norvegicus
Analyze
Symbol: Cdc25a
Name: cell division cycle 25A
Description: Exhibits phosphoprotein phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Localizes to the cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cell division cycle 25 homolog A (S. cerevisiae); cell division cycle 25 homolog A (S. pombe); dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1
Orthologs:
Homo sapiens (human) : CDC25A (cell division cycle 25A)  HGNC  Alliance
Mus musculus (house mouse) : Cdc25a (cell division cycle 25A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc25a (cell division cycle 25A)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC25A (cell division cycle 25A)
Canis lupus familiaris (dog) : CDC25A (cell division cycle 25A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc25a (cell division cycle 25A)
Sus scrofa (pig) : CDC25A (cell division cycle 25A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)Ensembl
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Celera8109,154,287 - 109,172,351 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Cdc25a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621498
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.