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Gene: Grk4 (G protein-coupled receptor kinase 4) Mus musculus
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Symbol: Grk4
Name: G protein-coupled receptor kinase 4
Description: Predicted to have rhodopsin kinase activity. Predicted to be involved in G protein-coupled receptor internalization and protein phosphorylation. Predicted to localize to cytosol; dendrite; and neuronal cell body. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; kinin signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A830025H08Rik; G protein-coupled receptor kinase 2, groucho gene related; g protein-coupled receptor kinase 2, groucho gene related (drosophila); g protein-coupled receptor kinase GRK4; Gprk2l; Gprk4; GRK
Orthologs:
Homo sapiens (human) : GRK4 (G protein-coupled receptor kinase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk4 (G protein-coupled receptor kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk4 (G protein-coupled receptor kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK4 (G protein-coupled receptor kinase 4)
Canis lupus familiaris (dog) : GRK4 (G protein-coupled receptor kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk4 (G protein-coupled receptor kinase 4)
Sus scrofa (pig) : GRK4 (G protein-coupled receptor kinase 4)
Chlorocebus sabaeus (African green monkey) : GRK4 (G protein-coupled receptor kinase 4)
Heterocephalus glaber (naked mole-rat) : Grk4 (G protein-coupled receptor kinase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl534,660,379 - 34,755,305 (+)EnsemblGRCm38mm10GRCm38
GRCm38534,660,250 - 34,755,305 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37535,003,028 - 35,097,952 (+)NCBIGRCm37mm9NCBIm37
MGSCv36534,977,810 - 35,072,160 (+)NCBImm8
Celera532,133,988 - 32,229,425 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Grk4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62150
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.