Gene: Ctsb (cathepsin B) Rattus norvegicus
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Symbol: Ctsb
Name: cathepsin B
Description: Exhibits several functions, including cysteine-type endopeptidase activity, kininogen binding activity, and peptide binding activity; involved in several processes, including autophagy, cellular response to mechanical stimulus, and negative regulation of cell death; localizes to several cellular components, including the apical plasma membrane, cytoplasm, and external side of plasma membrane; colocalizes with the caveola and perinuclear region of cytoplasm; used to study hepatocellular carcinoma and malignant glioma; biomarker of several diseases, including artery disease (multiple), cerebrovascular disease (multiple), fascioliasis, fatty liver disease, and otitis media; orthologous to human CTSB (cathepsin B); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cathepsin B1; RSG-2
Orthologs:
Homo sapiens (human) : CTSB (cathepsin B)  HGNC  Alliance
Mus musculus (house mouse) : Ctsb (cathepsin B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsb (cathepsin B)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSB (cathepsin B)
Canis lupus familiaris (dog) : CTSB (cathepsin B)
Sus scrofa (pig) : CTSB (cathepsin B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ctsb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621509
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.