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Gene: Ctsb (cathepsin B) Rattus norvegicus
Symbol: Ctsb
Name: cathepsin B
Description: Exhibits several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to ethanol; and response to interleukin-4. Localizes to several cellular components, including apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and malignant glioma. Biomarker of several diseases, including cerebrovascular disease (multiple); fascioliasis; fatty liver disease; polycystic kidney disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cathepsin B1; RSG-2
Homo sapiens (human) : CTSB (cathepsin B)  HGNC  Alliance
Mus musculus (house mouse) : Ctsb (cathepsin B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsb (cathepsin B)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSB (cathepsin B)
Canis lupus familiaris (dog) : CTSB (cathepsin B)
Sus scrofa (pig) : CTSB (cathepsin B)
Chlorocebus sabaeus (African green monkey) : CTSB (cathepsin B)
Heterocephalus glaber (naked mole-rat) : Ctsb (cathepsin B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ctsb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621509
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.