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Gene: Vcp (valosin-containing protein) Rattus norvegicus
Symbol: Vcp
Name: valosin-containing protein
Description: Exhibits several functions, including ATPase activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of synapse organization. Localizes to several cellular components, including VCP-NPL4-UFD1 AAA ATPase complex; VCP-NSFL1C complex; and glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
Also known as: 15S Mg(2+)-ATPase p97 subunit; TER ATPase; transitional endoplasmic reticulum ATPase
Homo sapiens (human) : VCP (valosin containing protein)  HGNC  Alliance
Mus musculus (house mouse) : Vcp (valosin containing protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vcp (valosin containing protein)
Pan paniscus (bonobo/pygmy chimpanzee) : VCP (valosin containing protein)
Canis lupus familiaris (dog) : VCP (valosin containing protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vcp (valosin containing protein)
Sus scrofa (pig) : VCP (valosin containing protein)
Chlorocebus sabaeus (African green monkey) : VCP (valosin containing protein)
Heterocephalus glaber (naked mole-rat) : Vcp (valosin containing protein)
more info ...
Allele / Splice: Vcpem1Ionsz  
Genetic Models: SD-Vcpem1Ionsz
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0558,426,548 - 58,445,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,426,549 - 58,445,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,951,999 - 62,971,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,472,100 - 59,491,508 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1559,472,279 - 59,491,687 (-)NCBI
Celera555,799,589 - 55,818,873 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Vcp
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621595
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.