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Gene: Itga6 (integrin subunit alpha 6) Rattus norvegicus
Symbol: Itga6
Name: integrin subunit alpha 6
Description: Exhibits laminin binding activity. Involved in cell-cell adhesion; cellular response to organic cyclic compound; and positive regulation of cell-substrate adhesion. Localizes to adherens junction; filopodium; and integrin alpha6-beta4 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: integrin alpha-6; integrin, alpha 6
Homo sapiens (human) : ITGA6 (integrin subunit alpha 6)  HGNC  Alliance
Mus musculus (house mouse) : Itga6 (integrin alpha 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga6 (integrin subunit alpha 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA6 (integrin subunit alpha 6)
Canis lupus familiaris (dog) : ITGA6 (integrin subunit alpha 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga6 (integrin subunit alpha 6)
Sus scrofa (pig) : ITGA6 (integrin subunit alpha 6)
Chlorocebus sabaeus (African green monkey) : ITGA6 (integrin subunit alpha 6)
Heterocephalus glaber (naked mole-rat) : Itga6 (integrin subunit alpha 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0358,442,904 - 58,515,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,443,101 - 58,515,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0364,931,497 - 65,003,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,202,931 - 54,272,803 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1354,134,160 - 54,168,913 (+)NCBI
Celera356,160,628 - 56,232,455 (+)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Itga6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 621633
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.